Paroxetine (trade names Seroxat, Paxil) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It was released in 1992 by the pharmaceutical company GlaxoSmithKline. It is used to treat major depression, obsessive-compulsive, panic and social anxiety disorders in adult outpatients.
The efficacy of paroxetine for depression is comparable to that of older tricyclic antidepressants with fewer side effects.[1][2] Differences with newer antidepressants are subtler and mostly confined to side effects. It shares the common side effects and contraindications of other SSRIs, with high rates of nausea, somnolence, and sexual side effects. Unlike two other popular SSRI antidepressants fluoxetine and sertraline, paroxetine is associated with a clinically significant weight gain[3] and statistically significant increase in the risk of suicidal tendencies in both adults[4] and children.[5] Stopping paroxetine may result in a discontinuation syndrome.
The efficacy of paroxetine for depression is comparable to that of older tricyclic antidepressants with fewer side effects.[1][2] Differences with newer antidepressants are subtler and mostly confined to side effects. It shares the common side effects and contraindications of other SSRIs, with high rates of nausea, somnolence, and sexual side effects. Unlike two other popular SSRI antidepressants fluoxetine and sertraline, paroxetine is associated with a clinically significant weight gain[3] and statistically significant increase in the risk of suicidal tendencies in both adults[4] and children.[5] Stopping paroxetine may result in a discontinuation syndrome.
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