Fexofenadine hydrochloride (brand names include Allegra, Telfast and Fastofen) is an antihistamine drug used in the treatment of hayfever and similar allergy symptoms. It was developed as a successor of and alternative to terfenadine (brand names include Triludan and Seldane), an antihistamine with potentially serious contraindications. Fexofenadine, like other second and third-generation antihistamines, does not readily cross the blood-brain barrier, and so causes less drowsiness than first-generation histamine-receptor antagonists. It works by being an antagonist to the H1 receptor.[1]
It has been described as both second-generation[2] and third-generation.[3]
It has been described as both second-generation[2] and third-generation.[3]
In controlled clinical studies there were no interactions with other drugs that significantly affected the safety or effectiveness of fexofenadine.[citation needed]
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