Omeprazole (INN) (pronounced /owˈmejprəzowl/) is a proton pump inhibitor used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and Zollinger-Ellison syndrome. It was first marketed in the US in 1989 by AstraZeneca as the magnesium salt omeprazole magnesium under the brand names Losec and Prilosec, and is now also available from generic manufacturers under various brand names. Omeprazole is one of the most widely prescribed drugs internationally and is available over the counter in some countries.
As with all proton pump inhibitors, omeprazole is generally well tolerated. Some of the most frequent side effects of omeprazole (experienced by over 1% of those taking the drug) are headache, diarrhea, abdominal pain, nausea, dizziness, trouble awakening and sleep deprivation, although in clinical trials the incidence of these effects with omeprazole was mostly comparable to that found with placebo.[2]
Proton pump inhibitors may be associated with a greater risk of hip fractures [3], clostridium difficile diarrhea[4] and heart problems, including cardiac arrest.
Proton pump inhibitors may be associated with a greater risk of hip fractures [3], clostridium difficile diarrhea[4] and heart problems, including cardiac arrest.
Patients who are taking Plavix in combination with proton pump inhibiting drugs may be at a greater risk of stroke or heart attack
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